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Sudan Journal of Agricultural Research
Preliminary investigations on the acute toxicity of root and bark extracts
of Adenium obesum (forsk.), Apocynaceae to the white mice Mus musculus
A.E. A. Bala1, R. Delonne2, G. Grolleau 2 and N. H. H. Bashir1
Abstract:
As part of the on going search for new pesticides, the crude solvent
extracts of roots and stem bark of Adenlum obesum (Forsk.), Apocynaceae,
locally known as Megadery or Shagaret Elsim, were tested against Mus
musculus. These plant parts were first chopped and milled to a fine powder
and then subjected to extraction by three different solvents:
dichloromethane (DCM), methanol (MeOH) and water. The LD50s within 24 hr
(per os) were found to be 9.69 and 22.10 g plantlkg body weight, for DCM and
water extracts of the roots, respectively. The symptoms of toxicity were
found to be: hyperthermy, hyperventilation, collapse and atony leading to
death. No acute mortality was recorded in the case of the MeOH-extract of the roots, nor for any of the three extracts of the bark.
Keywords:
Sudan Journal of Agricultural Research Vol. 1(1998) PP. 65-67
